C-terminal HSP90 Inhibitors Block the HSP90:HIF-1a Interaction and Inhibit the Cellular Hypoxic Response
N. Kataria, B. Kerr, S. Zaiter, S. R. McAlpine, K. M. Cook
This study shows C-terminal HSP90 inhibitors block HIF-1 stabilization under hypoxia, leading to HIF-1 degradation and reduced hypoxic gene expression in colorectal cancer cells.
bioRxiv · Jan 24, 2019 · PreprintCancer Biology