Immortalization of human zone I hepatocytes from biliary atresia with CDK4R24C, cyclin D1, and TERT for cytochrome P450 induction testing
M. Nishiwaki, M. Toyoda, Y. Oishi, S. Ishida, S.-i. Horiuchi, H. Makino, T. Kimura, S.-i. Ohno, T. Ohkura, S. Enosawa, H. Akutsu, A. Nakazawa, M. Kasahara, T. Kiyono, A. Umezawa
The paper describes the creation of an immortalized hepatocyte cell line, HepaMN, from biliary atresia tissue and demonstrates its utility for cytochrome P450 induction testing.
bioRxiv · Aug 8, 2019 · PreprintCell Biology