S.-U. Gorr

Resisting the resistance: The antimicrobial peptide DGL13K selects for small colony variants of Staphylococcus aureus that show increased resistance to its stereoisomer LGL13K, but not to DGL13K.

This study shows that exposure to antimicrobial peptides DGL13K and LGL13K leads to different resistance mechanisms in Staphylococcus aureus, with DGL13K selecting for resistance to LGL13K but not itself.

The oral pathogen Porphyromonas gingivalis resists the antimicrobial peptide LGL13K and evades the D-enantiomer by synonymous mutations in hagA

This study identifies synonymous mutations in hagA that confer resistance to DGL13K in P. gingivalis by altering mRNA structure and reducing HagA expression, without affecting mRNA levels.

The antimicrobial peptide DGL13K is active against resistant gram-negative bacteria and subinhibitory concentrations stimulate bacterial growth without causing resistance

The parotid secretory protein BPIFA2 is a salivary surfactant that affects LPS action

This study identifies BPIFA2 as a salivary surfactant that influences LPS activity and systemic responses in mice.