Altered follicular immunity in secondary lymphoid organs is associated with interferon hyperactivity in Down syndrome
Jeremías Dutto, Jeremías Bustos, Lucia Boffelli, Jimena Tosello-Boari, Jenny Christine Kienzler, Paula Araya, Sabrina Dhooge, Ana Paula Flores Guirado, Pilar Biasi, Ruth Eliana Baigorrí, Carina Valeriani, Wilfrid Richer, Cecilia del Carmen Montes, Virginia Cecconi, Burkhard Becher, , Mariana Maccioni
This study identifies altered follicular immunity and interferon hyperactivity in Down syndrome through single-cell and spatial profiling of human tonsils.
bioRxiv · Aug 9, 2026 · PreprintImmunology