Author

Paula Araya

University of Colorado AnschutzORCID 0000-0002-0340-5359Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Genetic & Genomic Medicine· 1 Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

Joaquin Maximiliano EspinosaiD· 3 shared Angela L. RachubinskiiD· 2 shared Belinda A Enriquez Estrada· 2 shared Eleanor C. Britton· 2 shared Hannah R. LyfordiD· 2 shared Katherine A. WaughiD· 2 shared Keith P. SmithiD· 2 shared Kelly D. SullivaniD· 2 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersImmunology

Joaquin Maximiliano EspinosaORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Altered follicular immunity in secondary lymphoid organs is associated with interferon hyperactivity in Down syndrome

Jeremías Dutto, Jeremías Bustos, Lucia Boffelli, Jimena Tosello-Boari, Jenny Christine Kienzler, Paula Araya, Sabrina Dhooge, Ana Paula Flores Guirado, Pilar Biasi, Ruth Eliana Baigorrí, Carina Valeriani, Wilfrid Richer, Cecilia del Carmen Montes, Virginia Cecconi, Burkhard Becher, , Mariana Maccioni

This study identifies altered follicular immunity and interferon hyperactivity in Down syndrome through single-cell and spatial profiling of human tonsils.

bioRxiv · Aug 9, 2026 · PreprintImmunology

JAK inhibition decreases the autoimmune burden in Down syndrome

Angela L. Rachubinski, Elizabeth B. Wallace, Emily Gurnee, Belinda A Enriquez Estrada, Kayleigh R Worek, Keith P. Smith, Paula Araya, Katherine A. Waugh, Ross E. Granrath, Eleanor C. Britton, Hannah R. Lyford, Micah G. Donovan, Neetha Paul Eduthan, Amanda A. Hill, Barry Martin, , Joaquin Maximiliano Espinosa

This study investigates immune dysregulation in Down syndrome and shows that JAK inhibition with tofacitinib reduces autoimmune symptoms and inflammatory markers without significant adverse effects.

eLife · Dec 31, 2024Peer-reviewedGenetic & Genomic Medicine

Interferon receptor gene dosage determines multiple hallmarks of Down syndrome

Katherine A. Waugh, Ross Minter, Jessica A Baxter, Congwu Chi, Kathryn D. Tuttle, Neetha Paul Eduthan, Matthew D. Galbraith, Kohl T. Kinning, Zdeněk Andrysík, Paula Araya, Hannah Dougherty, Lauren N. Dunn, Michael P. Ludwig, Kyndal A. Schade, Dayna Tracy, , Joaquin Maximiliano Espinosa

The paper shows that correcting interferon receptor gene dosage in a mouse model of trisomy 21 rescues multiple key phenotypes associated with Down syndrome.

bioRxiv · Feb 3, 2022 · PreprintGenetics