Activation of TPC2 amplifies lysosome-mitochondria calcium transfer to regulate energetic stress responses
Sadia Ahmed, Namratha Javvaji, Katherine L. Hammond, Kevin M. Casin, John W. Elrod, Paul M. Holloway, Yvonne Couch, Jillian N. Simon
This study shows TPC2 activation enhances lysosome-mitochondria calcium transfer, affecting mitochondrial function and stress responses, with implications for neuroprotection in stroke.
bioRxiv · Mar 4, 2026 · PreprintCell Biology