FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments
Raviprasad Kuthethur, Ananya Acharya, Satheesh Kumar Sengodan, Carmen Fonseca, Nupur Nagar, Safa Nasrin VZ, Oluwakemi Ibini, Eleni Maria Manolika, Kelly de Koning, Stefan Braunshier, Julien Dessapt, Amélie Fradet‐Turcotte, Joyce H.G. Lebbink, Roland Kanaar, Krishna Mohan Poluri, , Arnab Ray Chaudhuri
This study shows that FIGNL1 inhibits homologous recombination in BRCA2-deficient cells by preventing RAD51 filament removal, maintaining genome stability and viability.
bioRxiv · Nov 3, 2024 · PreprintGenetics