Amélie Fradet‐Turcotte

This study shows that FIGNL1 inhibits homologous recombination in BRCA2-deficient cells by preventing RAD51 filament removal, maintaining genome stability and viability.

The paper identifies C1orf112 as a novel regulator of interstrand crosslinks that decreases FIGNL1-RAD51 interaction, impairing homology-directed repair.

This paper characterizes the ZMYND11-MBTD1 fusion protein's role in oncogenesis by mislocalizing the NuA4/TIP60 complex to gene bodies, altering transcription and splicing, particularly of the MYC oncogene.

This study identifies two redundant ubiquitin-dependent pathways for BRCA1 localization to DNA damage sites, involving RAP80 and the BRCA1 RING domain.

ActiveDriverDB annotates disease mutations and population variants in post-translational modification sites using proteo-genomics data from multiple sources.