Author

Satheesh Kumar Sengodan

National Cancer InstituteORCID 0009-0002-8091-7937Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

Shyam K. SharaniD· 3 shared Arun Prakash MishraiD· 2 shared Amélie Fradet‐TurcotteiD· 1 shared Ananya AcharyaiD· 1 shared Arnab Ray ChaudhuriiD· 1 shared Carmen FonsecaiD· 1 shared Dillon Dierman· 1 shared Dylan Caylor· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersGenetics

Shyam K. SharanORCID

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Author profile →

3 papers

Recent·Most cited

A single BRCA2 BRC repeat supports viability while multiple repeats ensure resilience under stress

Arun Prakash Mishra, Sounak Sahu, Satheesh Kumar Sengodan, Gemma Moore, Swati Priya, Natasha Oberoi, Julia R. Jensen, Eileen A. Southon, Melissa Galloux, Dylan Caylor, Teresa L. Sullivan, Sandra Sczerba Burkett, Mary E. Albaugh, Parirokh P. Awasthi, Francesco Tomassoni‐Ardori, , Shyam K. Sharan

This study shows that a single BRC repeat supports viability in mice but multiple repeats enhance resilience under oxidative stress.

bioRxiv · Jan 8, 2026 · PreprintGenetics

5hmC enhances PARP trapping and restores PARP inhibitor sensitivity in chemoresistant BRCA1/2-deficient cells

Suhas S. Kharat, Arun Prakash Mishra, Satheesh Kumar Sengodan, Dillon Dierman, Stephen D. Fox, Walter Chazin, Shyam K. Sharan

This study shows that 5hmC increases PARP1 trapping on chromatin in olaparib-treated cells, restoring PARP inhibitor sensitivity in BRCA1/2-deficient cancer cells.

Journal of Biological Chemistry · Jun 19, 2025Peer-reviewedCancer Biology

FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments

Raviprasad Kuthethur, Ananya Acharya, Satheesh Kumar Sengodan, Carmen Fonseca, Nupur Nagar, Safa Nasrin VZ, Oluwakemi Ibini, Eleni Maria Manolika, Kelly de Koning, Stefan Braunshier, Julien Dessapt, Amélie Fradet‐Turcotte, Joyce H.G. Lebbink, Roland Kanaar, Krishna Mohan Poluri, , Arnab Ray Chaudhuri

This study shows that FIGNL1 inhibits homologous recombination in BRCA2-deficient cells by preventing RAD51 filament removal, maintaining genome stability and viability.

bioRxiv · Nov 3, 2024 · PreprintGenetics