Fetal reversion from diverse lineages sustains the intestinal stem cell pool and confers stress resilience
Sakura Kirino, Fumiya Uefune, Kensuke Miyake, Nobuhiko Ogasawara, Sakurako Kobayashi, Satoshi Watanabe, Yui Hiraguri, Go Ito, Keiichi Akahoshi, Daisuke Ban, Johan H. van Es, Hans C. Clevers, Mamoru Watanabe, Ryuichi Okamoto, Shiro Yui
This study shows that fetal reversion from diverse lineages sustains the intestinal stem cell pool and enhances stress resilience through bidirectional interconversion between CBCs and revSCs.
Communications Biology · Jan 13, 2026Peer-reviewedCell Biology