Johan H. van Es

This study develops a human organoid model to investigate interferon-gamma's effects on alveolar epithelial cell regeneration, showing divergent impacts on AT1 and AT2 cells.

This study shows that fetal reversion from diverse lineages sustains the intestinal stem cell pool and enhances stress resilience through bidirectional interconversion between CBCs and revSCs.

The paper shows that human embryo implantation involves Syncytin-2/MFSD2A-mediated cell fusion between blastoids and endometrial epithelial cells, preventing implantation when MFSD2A is knocked out.

The paper generates intestinal organoids from pediatric IBD patients and controls to study epithelial phenotypes linked to genetic drivers of the disease, identifying gene expression patterns and pathways associated with inflammation.

The paper shows that BEST4/CA7+ cells and goblet cells depend on each other for survival and differentiation in the intestinal mucus layer.