DNA damage drives a unique, Alzheimer's disease-relevant senescent state in neurons
Jun‐Wei B. Hughes, Anja Sandholm, Duncan Croll, Fiona Senchyna, Kevin Schneider, Rachel Butterfield, Tyne L.M. McHugh, Ian Brown, Hideto Deguchi, Tyler A. U. Hilsabeck, Sally K. Mak, Kenneth A. Wilson, Hayk Davtyan, Mathew M. Blurton-Jones, Joseph R. Herdy, , Judith Campisi
This study shows DNA damage in neurons leads to a senescent-like state similar to Alzheimer's disease, with distinct features from fibroblasts.
bioRxiv · Apr 3, 2026 · PreprintCell Biology