Author

Tyne L.M. McHugh

Buck Institute for Research on AgingORCID 0000-0002-6750-5957Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Lisa EllerbyiD· 2 shared Anja Sandholm· 1 shared Birgit SchillingiD· 1 shared Charles A. SchurmaniD· 1 shared Danielle A. SimmonsiD· 1 shared David FurmaniD· 1 shared Duncan Croll· 1 shared Fiona SenchynaiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersCell Biology

Lisa EllerbyORCID

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3 papers

Recent·Most cited

Cell BiologybioRxivPreprintApr 3, 2026

DNA damage drives a unique, Alzheimer's disease-relevant senescent state in neurons

Jun‐Wei B. Hughes, Anja Sandholm, Duncan Croll…·Judith Campisi

This study shows DNA damage in neurons leads to a senescent-like state similar to Alzheimer's disease, with distinct features from fibroblasts.

3 citations

humanbulk RNA-seq

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NeurosciencebioRxivPreprintNov 2, 2025

Investigation of Neurons and Microglia from APOE3 Induced Pluripotent Stem Cells using Data-Independent Acquisitions on a ZenoTOF 7600

Jordan B. Burton, Tyne L.M. McHugh, Charles A. Schurman…·Birgit Schilling

This paper develops a proteomic workflow using data-independent acquisitions to analyze APOE3-derived neurons and microglia, identifying cell type-specific markers and pathways.

DOI 10.1101/2025.11.02.686128

humanproteomics

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NeuroscienceMolecular Therapy — Methods & Clinical DevelopmentPeer-reviewedJan 22, 2025

Human striatal progenitor cells that contain inducible safeguards and overexpress BDNF rescue Huntington's disease phenotypes in R6/2 mice

Danielle A. Simmons, Sridhar Selvaraj, Tingshuo Chen…·Frank M. Longo

This study shows that human striatal progenitor cells overexpressing BDNF and with inducible safety switches improve HD symptoms in R6/2 mice.

3 citations

mouseexperimental assay

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