Tyler A. U. Hilsabeck

This study shows that cellular senescence in IPF fibroblasts disrupts antiviral responses, leading to increased viral titers and altered inflammation.

This study shows DNA damage in neurons leads to a senescent-like state similar to Alzheimer's disease, with distinct features from fibroblasts.

This study identifies ADAM19 as a modulator of the senescence-associated secretory phenotype (SASP) and shows that its inhibition reduces gut permeability and senescence markers in multiple species.

The paper uses deep learning to predict replicative lifespan in yeast by analyzing metabolic flux distributions and identifies a core network of reactions that explain lifespan variance.

The paper identifies genetic mechanisms underlying diet-dependent lifespan and healthspan in D. melanogaster using GWAS and validates gene effects on lifespan and climbing ability.