Nucleolar stress controls mutant Huntingtin toxicity and monitors Huntington disease progression
Aynur Soenmez, Rasem Mustafa, Salome T. Ryll, Francesca Tuorto, Ludivine Wacheul, Donatella Ponti, Christian Litke, Tanja Hering, Kerstin Kojer, Jenniver Koch, Claudia Pitzer, Joachim Kirsch, Andreas Neueder, Grzegorz Kreiner, Denis L. J. Lafontaine, , Rosanna Parlato
This study shows that nucleolar stress affects mutant Huntingtin toxicity and progression in Huntington disease by altering rRNA maturation and NPM1 localization.
Cell Death and Disease · Dec 8, 2021Peer-reviewedNeuroscience