LRH-1 is a novel regulator of neutrophil-driven immune responses within the tumor microenvironment.
Yu Wang, Bryan Duong, Sam Keeley, Natalia Krawczyńska, Shruti V. Bendre, Claire P. Schane, Erin Weisser, Nadia Cobo‐Vuilleumier, Lara I. Kockaya, Y. Fei, Anasuya Das Gupta, Hashni Epa Vidana Gamage, Adam T. Nelczyk, Sisi He, Hannah H. Kim, , Erik Russell Nelson
This study identifies LRH-1 as a regulator of neutrophil behavior in the tumor microenvironment, showing its impact on migration, phagocytosis, T cell interaction, and NETosis, with implications for cancer recurrence and metastasis.
bioRxiv · Sep 16, 2025 · PreprintCancer Biology