Erik Russell Nelson

This study identifies ACSS2-mediated metabolic-epigenetic crosstalk as a driver of Fulvestrant resistance in ER+ breast cancer and presents ACSI as a potential therapeutic target.

This study links diet to mammary cancer recurrence via mast cell loss and histaminergic signaling, showing that H2R antagonists promote platelet-mediated NETosis and reemergence from dormancy.

This study shows how scaffold pore size, alignment, and glycosaminoglycan content influence macrophage polarization toward M2-like phenotypes in 3D mineralized collagen scaffolds.

The paper shows that MALAT1 long noncoding RNA forms condensates with splicing factors to regulate hypoxia-induced alternative splicing near nuclear speckles.

The paper investigates the role of CASM in STING signaling, finding that CASM enhances NFκB-driven TNF production while autophagy exerts negative feedback on STING pathways.

This study identifies ABCA1 as a cholesterol efflux protein that enhances anti-cancer functions of myeloid cells, with clinical relevance in breast tumors.

This study shows that 27HC-treated neutrophils release sEVs that induce EMT and stemness in breast cancer cells via WNT/β-catenin pathway activation.

This study identifies LRH-1 as a regulator of neutrophil behavior in the tumor microenvironment, showing its impact on migration, phagocytosis, T cell interaction, and NETosis, with implications for cancer recurrence and metastasis.

This study shows that 27-hydroxycholesterol increases EV secretion by impairing lysosomal function through mitochondrial ROS, and antioxidant treatment reverses this effect.