Time Course and Microcircuit Mechanisms of Primary Motor Cortex Dysfunction in Progressive Parkinsonism
Liqiang Chen, Hiba Douja Chehade, Samhitha Somavarapu, Hong‐Yuan Chu
This study identifies age- and dopamine-dependent synaptic and cellular changes in M1 neurons during progressive parkinsonism and shows that L-DOPA can prevent or rescue these adaptations.
bioRxiv · Jul 30, 2026 · PreprintNeuroscience