Author

Hiba Douja Chehade

Georgetown UniversityORCID 0000-0002-5959-7900Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:imaging· 2 Research Focus:trajectory inference· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1

Frequent Co-Authors

Hong‐Yuan ChuiD· 5 shared Daniil Berezhnoi· 3 shared Liqiang CheniD· 3 shared Samhitha Somavarapu· 2 shared Benjamin B. RiskiD· 1 shared Gabriel Simms· 1 shared Jitong Jiang· 1 shared Kishore Kumar S. NarasimhaniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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5 shared papersNeuroscience

Hong‐Yuan ChuORCID

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5 papers

Recent·Most cited

Time Course and Microcircuit Mechanisms of Primary Motor Cortex Dysfunction in Progressive Parkinsonism

Liqiang Chen, Hiba Douja Chehade, Samhitha Somavarapu, Hong‐Yuan Chu

This study identifies age- and dopamine-dependent synaptic and cellular changes in M1 neurons during progressive parkinsonism and shows that L-DOPA can prevent or rescue these adaptations.

bioRxiv · Jul 30, 2026 · PreprintNeuroscience

Emergence of Task-Related Motor Cortical Dysfunction in Mice with Progressive Parkinsonism

Hiba Douja Chehade, Daniil Berezhnoi, Samhitha Somavarapu, Zihang Wang, Jitong Jiang, Liqiang Chen, Benjamin B. Risk, Thomas Wichmann, Hong‐Yuan Chu

This study examines M1 circuit dysfunction in MitoPark mice during progressive Parkinsonism, finding reduced cellular activity and impaired neuronal coactivation linked to motor deficits.

bioRxiv · Jun 2, 2026 · PreprintNeuroscience

Sub-second analysis of locomotor activity in Parkinsonian mice

Daniil Berezhnoi, Hiba Douja Chehade, Gabriel Simms, Liqiang Chen, Kishore Kumar S. Narasimhan, Shashank Manohar Dravid, Hong‐Yuan Chu

This study uses machine learning to analyze locomotor behavior in Parkinsonian mice, revealing changes in behavioral module velocity and showing L-DOPA's effect on velocity but not usage or transitions.

eNeuro · Jul 28, 2025Peer-reviewedNeuroscience

Motor Cortical Neuronal Hyperexcitability Associated with α-Synuclein Aggregation

Liqiang Chen, Hiba Douja Chehade, Hong‐Yuan Chu

This study shows that α-synuclein aggregates in the motor cortex lead to neuronal hyperexcitability and structural changes, contributing to cortical dysfunction in Parkinson's disease.

npj Parkinson s Disease · Jan 14, 2025Peer-reviewedNeuroscience

Open-Source Platform for Kinematic Analysis of Mouse Forelimb Movement

Daniil Berezhnoi, Hiba Douja Chehade, Hong‐Yuan Chu

The paper introduces an open-source platform and software for analyzing mouse forelimb movement during a reach-to-grasp task, including hardware design, training protocols, and video analysis tools.

STAR Protocols · Jun 20, 2024Peer-reviewedNeuroscience