Thomas Wichmann

This study examines M1 circuit dysfunction in MitoPark mice during progressive Parkinsonism, finding reduced cellular activity and impaired neuronal coactivation linked to motor deficits.

The paper simulates Parkinson's disease effects on primary motor cortex neurons, showing increased beta band power in simulated networks.

The paper uses microendoscopic calcium imaging to study activity patterns of projection neurons in SMA and M1 of rhesus macaques during rest and arm movement.

This study examines the occurrence of repeating spike sequences in basal ganglia neurons of healthy and parkinsonian primates, finding that parkinsonism alters the proportion of sequence spikes in different brain regions.

The paper characterizes two ultrapotent chemogenetic ligands in rhesus macaques, showing good brain penetrance and safety for potential neuroscience research applications.