Hong‐Yuan Chu

This study identifies age- and dopamine-dependent synaptic and cellular changes in M1 neurons during progressive parkinsonism and shows that L-DOPA can prevent or rescue these adaptations.

This study examines M1 circuit dysfunction in MitoPark mice during progressive Parkinsonism, finding reduced cellular activity and impaired neuronal coactivation linked to motor deficits.

The paper simulates Parkinson's disease effects on primary motor cortex neurons, showing increased beta band power in simulated networks.

This study uses machine learning to analyze locomotor behavior in Parkinsonian mice, revealing changes in behavioral module velocity and showing L-DOPA's effect on velocity but not usage or transitions.

This study shows that α-synuclein aggregates in the motor cortex lead to neuronal hyperexcitability and structural changes, contributing to cortical dysfunction in Parkinson's disease.

This study shows that -synuclein aggregation disrupts cortico-amygdala connectivity, leading to social behavior deficits in synucleinopathies, and that restoring this connection can rescue the behavior.

The paper introduces an open-source platform and software for analyzing mouse forelimb movement during a reach-to-grasp task, including hardware design, training protocols, and video analysis tools.

This study investigates how alpha-synuclein aggregation in the basolateral amygdala affects glutamatergic transmission, finding that it selectively disrupts cortico-BLA synapses.

This study identifies reduced thalamic excitation to motor cortical pyramidal tract neurons in a mouse model of parkinsonism, mediated by NMDA receptor overactivation and reversible via chemogenetic suppression of basal ganglia outputs.

This study shows that motor cortical pyramidal neurons in Parkinsonism exhibit cell-type-specific decreases in intrinsic excitability due to impaired ion channel function.

The paper shows that restoring autonomous subthalamic nucleus activity through chemogenetics reduces synaptic synchronization and improves motor symptoms in Parkinson's disease models.