The Integrated Stress Response Pathway Improves Aged Murine Muscle Stem Cell Activation and in vivo Regeneration.
Alexander D. Brown, Annarita Scaramozza, Hanzhi Zhang, Samiha Mahin, Nivedita Suresh, Takeshi Tsusaka, Susan Eliazer, Xuhui Liu, Brian Thomas Feeley, Andrew S. Brack
This study identifies the Integrated Stress Response (ISR) pathway as a regulator of aged muscle stem cell activation and regeneration, showing pharmacological ISR activation improves their function and muscle repair.
bioRxiv · Sep 26, 2025 · PreprintCell Biology