Andrew S. Brack

Control of Quiescence and Activation of Human Muscle Stem Cells by Cytokines

This study identifies cytokine signaling pathways involved in human satellite cell activation and shows their potential for muscle repair applications.

The Integrated Stress Response Pathway Improves Aged Murine Muscle Stem Cell Activation and in vivo Regeneration.

This study identifies the Integrated Stress Response (ISR) pathway as a regulator of aged muscle stem cell activation and regeneration, showing pharmacological ISR activation improves their function and muscle repair.

Aging induces aberrant state transition kinetics in murine muscle stem cells

This study finds that aged murine muscle stem cells have delayed activation kinetics but retain a youthful activation trajectory, suggesting changes in state transition dynamics contribute to aging.

Deep convolutional and recurrent neural networks for cell motility discrimination and prediction

This paper develops CNN and LSTM models to classify and predict cell motility, achieving performance comparable to hand-engineered features and showing utility in predicting muscle stem cell motility.