Treatment with the ribosome biogenesis inhibitor CX-5461 increases platelet count in humans and enhances murine megakaryopoiesis
Vijay Bhoopalan, Amandeep Kaur, James I. Hearn, Kylee H. Maclachlan, Lixinyu Liu, Rita Ferreira, Sidra Asad Ali, Yee Lin Thong, Nadine Hein, Samina Nazir, Simone A. Brysland, Si Ming Man, Simon James Harrison, Robert K. Andrews, Koji Eto, , Elizabeth E. Gardiner
The paper shows that CX-5461, a ribosome biogenesis inhibitor, increases platelet counts in humans and enhances megakaryopoiesis in mice without affecting platelet function or inflammatory cytokines.
bioRxiv · Jun 15, 2025 · PreprintCell Biology