Cell BiologybioRxivPreprint
Treatment with the ribosome biogenesis inhibitor CX-5461 increases platelet count in humans and enhances murine megakaryopoiesis
Vijay Bhoopalan, Amandeep Kaur, James I. Hearn…·Elizabeth E. Gardiner
The paper shows that CX-5461, a ribosome biogenesis inhibitor, increases platelet counts in humans and enhances megakaryopoiesis in mice without affecting platelet function or inflammatory cytokines.