Author

Samuel Alexander Leach

Northwestern University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Danielle Tullman‐ErcekiD· 2 shared Jordan Scott SummersiD· 2 shared Bon C. Ikwuagwu· 1 shared Edward Wen· 1 shared Lisa Ann BurdetteiD· 1 shared Nolan W. KennedyiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 12 mutual co-author links

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2 shared papersSynthetic Biology

Danielle Tullman‐ErcekORCID

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2 papers

Recent·Most cited

A High Throughput Assay for Measuring Secreted Protein Based on a de novo Fluorescent Reporter Reveals Regulatory and Structural Insights in Salmonella Type Three Secretion System

Samuel Alexander Leach, Jordan Scott Summers, Edward Wen, Danielle Tullman‐Ercek

The paper develops a high-throughput assay using a de novo fluorescent reporter to measure secreted protein via the Salmonella T3SS, revealing regulatory and structural insights.

Protein Science · Jun 25, 2025Peer-reviewedSynthetic Biology

Characterization and Engineering of the Type 3 Secretion System Needle Monomer from Salmonella Through the Construction and Screening of a Comprehensive Mutagenesis Library

Lisa Ann Burdette, Samuel Alexander Leach, Nolan W. Kennedy, Bon C. Ikwuagwu, Jordan Scott Summers, Danielle Tullman‐Ercek

This paper constructs and screens a mutagenesis library of the PrgI protein to identify mutations that enhance T3SS secretion titer and establish design rules for engineering the secretion system.

mSphere · Aug 7, 2024Peer-reviewedBioengineering