Cortical RORβ is required for layer 4 transcriptional identity and barrel integrity.
Erin Clark, Michael L. Rutlin, Lucia S Capano, Samuel Aviles, Jordan Raphael Saadon, Praveen Taneja, Qiyu Zhang, James B. Bullis, Timothy Lauer, Emma M. Myers, Anton Schulmann, Douglas Forrest, Sacha B. Nelson
This study shows RORβ is essential for layer 4 transcriptional identity and barrel structure in the cortex, with loss of RORβ disrupting gene expression, chromatin accessibility, and thalamocortical afferent organization.
eLife · Aug 27, 2020Peer-reviewedNeuroscience