The paper identifies a transcriptional switch in KLF activators and repressors during postnatal neuronal maturation using CRISPRi and integrates chromatin and gene expression data.

eLife · Oct 20, 2026Peer-reviewedNeuroscience

Cortical RORβ is required for layer 4 transcriptional identity and barrel integrity.

Erin Clark, Michael L. Rutlin, Lucia S Capano, Samuel Aviles, Jordan Raphael Saadon, Praveen Taneja, Qiyu Zhang, James B. Bullis, Timothy Lauer, Emma M. Myers, Anton Schulmann, Douglas Forrest, Sacha B. Nelson

This study shows RORβ is essential for layer 4 transcriptional identity and barrel structure in the cortex, with loss of RORβ disrupting gene expression, chromatin accessibility, and thalamocortical afferent organization.

eLife · Aug 27, 2020Peer-reviewedNeuroscience

The Transcriptional Logic of Mammalian Neuronal Diversity

Ken Sugino, Erin Clark, Anton Schulmann, Yasuyuki Shima, Lihua Wang, David L. Hunt, Bryan M. Hooks, Dimitri Tränkner, Jayaram V. Chandrashekar, Serge Picard, Andrew L. Lemire, Nelson Spruston, Adam W. Hantman, Sacha B. Nelson

The paper identifies homeobox transcription factors as key drivers of neuronal diversity through improved expression metrics and links long genes to regulatory elements and mobile elements.

bioRxiv · Oct 24, 2017 · PreprintEvolutionary Biology