Qiyu Zhang

Cell type-resolved connectomic reconstruction of the spinal dorsal horn reveals sensory neuron synaptic organization and modality-specific inhibition

The paper presents tools to reconstruct spinal cord circuits and identifies modality-specific inhibitory synapses between sensory neurons and inhibitory neurons.

A synaptic wiring diagram underlying modality-specific ascending pathways of the superficial spinal dorsal horn

The paper maps synaptic connections in the mouse spinal dorsal horn to show how different sensory modalities are routed through distinct pathways to the brain.

Three-dimensional reconstructions of mechanosensory end organs suggest a unifying mechanism underlying dynamic, light touch

This study uses 3D reconstructions of mechanosensory end organs to propose a unified mechanism for Aβ RA-LTMR activation through axon protrusions and Piezo2 distribution.

γ-Protocadherins control synapse formation and peripheral branching of touch sensory neurons

This study shows that γ-protocadherin isoforms are critical for synapse formation and peripheral branching in touch sensory neurons, and their loss disrupts corticospinal synapses.

A role for axon-glial interactions and Netrin-G1 signaling in the formation of low-threshold mechanoreceptor end organs

Cortical RORβ is required for layer 4 transcriptional identity and barrel integrity.

This study shows RORβ is essential for layer 4 transcriptional identity and barrel structure in the cortex, with loss of RORβ disrupting gene expression, chromatin accessibility, and thalamocortical afferent organization.