Using a stable protein scaffold to display peptides that bind to alpha-synuclein fibrils
Samuel Bismut, Matthias M. Schneider, Masashi Miyasaki, Yuqing Feng, Ellis J. Wilde, M. Dylan Gunawardena, Tuomas P. J. Knowles, Gabriele S. Kaminski Schierle, Laura S. Itzhaki, Janet R. Kumita
The paper demonstrates that stable CTPR proteins can be modified to bind alpha-synuclein fibrils with micromolar affinity, enabling the testing of fibril-binding peptides.
Protein Science · May 15, 2025Peer-reviewedBiochemistry