Author
University of CambridgeORCID 0000-0002-1894-1859Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Matthew W. Cotton, Shriram Venkatesan, Joseph S. Beckwith…·Georg Meisl
The paper identifies a cellular tipping point between aggregate accumulation and removal as a universal feature of neurodegeneration, validated through live-cell assays and super-resolution imaging.
Samuel Bismut, Matthias M. Schneider, Masashi Miyasaki…·Janet R. Kumita
The paper demonstrates that stable CTPR proteins can be modified to bind alpha-synuclein fibrils with micromolar affinity, enabling the testing of fibril-binding peptides.
Yihan Yao, Nadia A. Erkamp, Tomas Šneideris…·Tuomas P. J. Knowles
The paper investigates thyroglobulin phase separation in thyroid follicles, showing it forms storage depots and reveals a mechanism for hormone homeostasis.
Danny D. Sahtoe, Ewa A. Andrzejewska, Hannah L. Han…·David A. Baker
The paper designs peptide traps that bind amyloidogenic segments in {beta}-strand and {beta}-hairpin conformations, effectively blocking fibril assembly for A{beta}42.