pertTF: context-aware AI modeling for genome-scale and cross-system perturbation prediction
Yangqi Su, Dingyu Liu, Vipin K. Menon, Bicna Song, Samuel Boccara, Nan Zhang, Huan Zhao, Jiahui Hazel Zhao, Lei Wang, Nan Hu, Mpathi Nzima, Alon Katz, Bharath Kumar Swargam, Seth A. Ament, Yarui Diao, , Wei Li
The paper introduces pertTF, a transformer-based model for predicting genetic perturbation responses, showing improved performance in expression prediction and cell identity shifts across cellular contexts.
bioRxiv · Mar 16, 2026 · PreprintBioinformatics