Author

Nan Zhang

Howard Hughes Medical InstituteORCID 0000-0002-9675-5322Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Nan Zhang6 papers · Northeast Agricultural University

Biology Disciplines

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Neuroscience· 2 Bioinformatics· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:database / resource· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Danwei HuangfuiD· 2 shared Nan Hu· 2 shared Alon Katz· 1 shared Ann Le· 1 shared Anthony J. Intorcia· 1 shared Berk TurhaniD· 1 shared Bharath Kumar SwargamiD· 1 shared Bicna SongiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersGenetics

Danwei HuangfuORCID

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Author profile →

4 papers

Recent·Most cited

A dish-to-biobank framework links β-cell nutrient-stress programs to genetic and dietary risk for Type 2 Diabetes

Xianming Wang, Hanbyul Lee, Ann Le, Berk Turhan, Nan Hu, Pretty S. Garcia, Xuewei Cao, D K Liu, Thahmina A. Ali, Nan Zhang, Breanna Williams, Caleb A. Lareau, G M Wang, Danwei Huangfu, Kushal K. Dey

bioRxiv · Jun 16, 2026 · PreprintGenetics

pertTF: context-aware AI modeling for genome-scale and cross-system perturbation prediction

Yangqi Su, Dingyu Liu, Vipin K. Menon, Bicna Song, Samuel Boccara, Nan Zhang, Huan Zhao, Jiahui Hazel Zhao, Lei Wang, Nan Hu, Mpathi Nzima, Alon Katz, Bharath Kumar Swargam, Seth A. Ament, Yarui Diao, , Wei Li

The paper introduces pertTF, a transformer-based model for predicting genetic perturbation responses, showing improved performance in expression prediction and cell identity shifts across cellular contexts.

bioRxiv · Mar 16, 2026 · PreprintBioinformatics

Regulation of Glypican 6-mediated Wnt activation maintains TDP-43 nuclear localization in neurons

Nan Zhang, Shanthini Sockanathan

This study identifies a signaling axis involving GDE2, GPC6, and the Wnt pathway that regulates NPC integrity and TDP-43 nuclear localization in neurons.

Scientific Reports · Dec 11, 2025Peer-reviewedNeuroscience

Severe Hyposmia Distinguishes Neuropathologically Confirmed Dementia with Lewy Bodies from Alzheimer’s Disease Dementia

Thomas G. Beach, Charles H. Adler, Nan Zhang, Geidy E. Serrano, Lucia I. Sue, Erika D. Driver‐Dunckley, Shyamal H. Mehta, E Zamrini, Marwan Noel Sabbagh, Holly A. Shill, Christine M. Belden, David Shprecher, Richard J. Caselli, Eric M. Reiman, Kathryn J. Davis, , Richard C. Gerkin

This study finds that severe hyposmia (reduced sense of smell) is a distinguishing feature between dementia with Lewy bodies and Alzheimer’s disease dementia, based on neuropathological confirmation.

PLoS ONE · Apr 22, 2020Peer-reviewedNeuroscience