Yarui Diao

The paper investigates transcriptional changes in VTA neurons after chronic cocaine cessation and their role in relapse, finding that BDNF transcription is causally linked to cocaine seeking.

The paper introduces pertTF, a transformer-based model for predicting genetic perturbation responses, showing improved performance in expression prediction and cell identity shifts across cellular contexts.

The paper uses in vivo proteomics and CRISPR screening to identify STXBP1 as a protective factor against α-synuclein toxicity in dopamine neurons in Parkinson's disease models.

The paper shows that increasing RNA Polymerase II levels enhances mRNA content and drives myofiber growth without needing additional nuclei.

The paper identifies mechanoenhancers that regulate transcription in response to matrix stiffness and shows their potential for reprogramming cellular responses to mechanical cues.

The paper identifies a gene regulatory element that modulates MYH6 expression and influences cardiomyocyte response to stress.

The paper identifies Vcam1+ fibro-adipogenic progenitors as markers of fatty infiltration in chronic limb threatening ischemia using single-cell transcriptomics in mouse models.

This study shows that UBE2N is crucial for skin homeostasis and inflammation suppression, with its loss causing inflammatory skin defects and identifying IRAK1/4 as a therapeutic target.

This study identifies pro-inflammatory macrophages as a key factor impairing skeletal muscle regeneration in ischemic-damaged limbs by inducing premature differentiation of satellite cells.

The paper introduces a method to quantify diverse perturbation responses and discover novel biological insights in single-cell perturbation datasets.

This paper develops a synthetic niche to expand nephron progenitor cells, enabling organoid generation and CRISPR screening for kidney development and disease.

The paper introduces HiCAR, a method that simultaneously assesses chromatin accessibility, interactions, and transcriptome in low-input samples, revealing 46,792 cis-regulatory interactions in H1 hESCs.