Divergent age-dependent conformational rearrangement within Aβ-amyloid deposits in APP23, APPPS1, and AppNL-F mice
Farjana Parvin, Samuel Haglund, Bettina M. Wegenast‐Braun, Mathias Jucker, Takashi Saito, Takaomi C. Saido, K. Peter R. Nilsson, Per Nilsson, Sofie Nyström, Per Hammarström
This paper compares Aβ fibril structures in three mouse models of Alzheimer's disease, finding age-dependent differences in plaque morphology and polymorph maturation.
ACS Chemical Neuroscience · Apr 23, 2024Peer-reviewedNeuroscience