Genomic loss of GPR108 disrupts AAV transduction in birds
Alexander A. Nevue, Anusha Sairavi, Samuel J. Huang, Hiroyuki Nakai, Claudio V. Mello
The paper shows that GPR108 absence in birds explains lower AAV transduction efficacy and demonstrates that human GPR108 expression and capsid modifications enhance transduction in zebra finch cells.
bioRxiv · May 16, 2024 · PreprintGenomics