The Eya1 phosphatase mediates Shh-driven symmetric cell division of cerebellar granule cell precursors
Daniel J. Merk, Pengcheng Zhou, Samuel M. Cohen, Maria F. Pazyra‐Murphy, Grace H. Hwang, Kristina J. Rehm, Jose Alfaro, Christopher M. Reid, Xuesong Zhao, Eunyoung Park, Pin‐Xian Xu, Jennifer Ai-wen Chan, Michael J. Eck, Kellie J. Nazemi, Corey C. Harwell, Rosalind A. Segal
This study identifies the Shh-Eya1 regulatory axis as critical for promoting symmetric cell divisions in cerebellar granule cell precursors by coordinating spindle orientation and cell fate determinants.
Developmental Neuroscience · Jan 1, 2020Peer-reviewedNeuroscience