Maria F. Pazyra‐Murphy

The paper identifies compartment-specific translational programs in sensory neuron axons using spatial translatomics and shows that RNA-binding proteins guide mRNA sorting to establish molecular identities.

This study integrates single-cell and spatial transcriptomics with live-cell imaging to characterize tumor heterogeneity in supratentorial ependymomas, revealing distinct progenitor-like states and spatial organization patterns.

This study shows that co-culturing human iPSC-derived sensory neurons with rodent satellite glia enhances their differentiation and maturation, leading to more mature phenotypes and improved disease modeling.

This study shows that paclitaxel induces cADPR production via Sarm1, increasing intra-axonal calcium and causing axon degeneration, with cADPR antagonists preventing neuropathy without affecting chemotherapy efficacy.

This study uses single-cell RNA sequencing to analyze developing and mature glia in peripheral sensory ganglia, revealing transcriptional differences and shared molecular features across glial subtypes.

This study identifies the Shh-Eya1 regulatory axis as critical for promoting symmetric cell divisions in cerebellar granule cell precursors by coordinating spindle orientation and cell fate determinants.