Corey C. Harwell

Mu opioid receptor mRNA and protein localization across the rat and mouse habenula

The paper maps mu opioid receptor mRNA and protein expression in the habenula of rat and mouse, showing expression in both medial and lateral subdivisions with differences in cell proportions and localization.

Progenitor Diversity and Architecture of the Human Ganglionic Eminences Shaping the Basal Ganglia

The paper identifies distinct progenitor populations in human ganglionic eminences, their gene regulatory networks, and lineage trajectories using single-nucleus transcriptomics and spatial transcriptomics.

Conservation, alteration, and redistribution of mammalian striatal interneurons

The paper analyzes the conservation and evolution of striatal interneurons across mammals, finding that TAC3 interneurons are conserved and that neuronal types evolve through redistribution and refinement.

Multimodal classification of neurons in the lateral septum

The paper identifies 22 molecularly distinct neuronal subtypes in the lateral septum by profiling transcriptional identity and examines their connectivity, morphology, and electrophysiology.

PRDM16 co-operates with LHX2 to shape the human brain

The paper investigates PRDM16's role in human brain development by analyzing a patient mutation and cortical organoids, revealing its collaboration with LHX2 in gene regulation.

Developmental origin and local signals cooperate to determine septal astrocyte identity

The paper shows that intrinsic developmental origins and local signals shape septal astrocyte identity through distinct molecular and morphological features in medial and lateral septal nuclei.

Selective loss of Nkx2.1-lineage neurons in the lateral septum alters the balance between novelty seeking and threat avoidance

Temporal and sequential transcriptional dynamics define lineage shifts in corticogenesis

The paper maps transcriptional dynamics in murine cortical development, identifying lineage shifts and gene regulatory networks in neural stem cells, basal progenitors, and newborn neurons.

Transcriptional profiling of sequentially generated septal neuron fates

The paper uses single-cell RNA sequencing to study how transcriptional changes during neurogenesis lead to the sequential generation of distinct septal neuron types.

Astrocyte-neuron crosstalk through Hedgehog signaling mediates cortical circuit assembly

This study shows that Sonic hedgehog signaling from cortical neurons regulates astrocyte development and synaptic connectivity during cortical circuit formation.

Cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region specific manner

The paper identifies that cortical ChAT+ neurons co-transmit acetylcholine and GABA in a target- and brain-region specific manner, revealing heterogeneity in their function and connectivity.

Transcriptional regulation of MGE progenitor proliferation by PRDM16 controls cortical GABAergic interneuron production

This study shows PRDM16 regulates MGE progenitor proliferation and GABAergic interneuron production by repressing differentiation genes.

The Eya1 phosphatase mediates Shh-driven symmetric cell division of cerebellar granule cell precursors

This study identifies the Shh-Eya1 regulatory axis as critical for promoting symmetric cell divisions in cerebellar granule cell precursors by coordinating spindle orientation and cell fate determinants.

Sonic hedgehog signaling in astrocytes mediates cell-type-specific synaptic organization

This study shows that Sonic hedgehog signaling in astrocytes is required for cell-type-specific synaptic organization and remodeling in the cortex.