Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters
Ernest Palomer, Núria Martín‐Flores, Sarah Jolly, Patricia Pascual Vargas, Stefano Benvegnù, Marina Podpolny, Samuel Teo, Kadi Vaher, Takashi Saito, Takaomi C. Saido, Paul John Whiting, Patricia C. Salinas
The paper identifies Sirt2-induced H4K16ac deacetylation of Fzd1 and Fzd7 promoters as a mechanism repressing Wnt signaling in Alzheimer's disease.
Molecular Psychiatry · Mar 16, 2022Peer-reviewedNeuroscience