Author

Patricia C. Salinas

University College LondonORCID 0000-0002-5748-083XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 5 Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Marina PodpolnyiD· 3 shared Núria Martín‐FloresiD· 2 shared Paul John WhitingiD· 2 shared Sarah JollyiD· 2 shared Alasdair J. GibbiD· 1 shared Bart De StrooperiD· 1 shared Bernadett KalmáriD· 1 shared Blanka R. Szulc· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersNeuroscience

Marina PodpolnyORCID

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5 papers

Recent·Most cited

NeuroscienceeLifePeer-reviewedSep 25, 2023

Downregulation of Dickkopf-3, a Wnt antagonist elevated in Alzheimer's disease, restores synapse integrity and memory in a disease mouse model

Núria Martín‐Flores, Marina Podpolny, Faye McLeod…·Patricia C. Salinas

This study shows that DKK3, a Wnt antagonist elevated in Alzheimer's disease, causes synaptic loss and memory impairment, but its knockdown restores synapse integrity and memory in a mouse model.

15 citations

mouseexperimental assay

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NeurosciencebioRxivPreprintMay 5, 2022

Microglial expression of the Wnt signalling modulator DKK2 differs between human Alzheimer's disease brains and mouse neurodegeneration models

Nozie D. Aghaizu, Sarah Jolly, Satinder K. Samra…·Paul John Whiting

This study compares microglial DKK2 expression in mouse AD models and human AD brains, finding upregulation in mice but not in humans.

1 citation

mousehuman

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NeurosciencebioRxivPreprintApr 6, 2022

A genetic variant of the Wnt receptor LRP6 accelerates synapse degeneration during ageing and in Alzheimer's disease

Megan E. Jones, Johanna Buechler, Tom Dufor…·Patricia C. Salinas

2 citations

mouseexperimental assay

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NeuroscienceMolecular PsychiatryPeer-reviewedMar 16, 2022

Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters

Ernest Palomer, Núria Martín‐Flores, Sarah Jolly…·Patricia C. Salinas

The paper identifies Sirt2-induced H4K16ac deacetylation of Fzd1 and Fzd7 promoters as a mechanism repressing Wnt signaling in Alzheimer's disease.

42 citationstop 2%

humanmouse

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NeuroscienceeLifePeer-reviewedJun 30, 2021

Miro1-dependent Mitochondrial Dynamics in Parvalbumin Interneurons

Georgina Kontou, Pantelis Antonoudiou, Marina Podpolny…·Josef T. Kittler

This study investigates the role of Miro1 in mitochondrial dynamics of parvalbumin interneurons and shows its impact on neuronal signaling and network synchronization.

36 citations

mouseimaging

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