Author

Sarah Jolly

Alzheimer’s Research UKORCID 0000-0003-1297-0058Unclaimed ORCID profile · follow to get notified of new preprints

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

Paul John WhitingiD· 4 shared Leela Phadke· 2 shared Lucy GranatiD· 2 shared Nozie D. AghaizuiD· 2 shared Patricia C. SalinasiD· 2 shared Satinder K. Samra· 2 shared Argyro AlatzaiD· 1 shared Bart De StrooperiD· 1 shared

Activity by Year

2022-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersNeuroscience

Paul John WhitingORCID

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4 papers

Recent·Most cited

NeuroscienceMolecular NeurodegenerationPeer-reviewedJun 20, 2025

Mutations in PSEN1 predispose inflammation in an astrocyte model of familial Alzheimer's disease through disrupted regulated intramembrane proteolysis

Oliver Jonathan Ziff, Gustavo Morrone Parfitt, Sarah Jolly…·Charles Arber

This study shows that PSEN1 mutations disrupt regulated intramembrane proteolysis in astrocytes, leading to enhanced inflammatory responses and contributing to familial Alzheimer's disease progression.

5 citations

humanbulk RNA-seq

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NeuroscienceFrontiers in Aging NeurosciencePeer-reviewedDec 1, 2022

A primary rodent triculture model to investigate the role of glia-neuron crosstalk in regulation of neuronal activity.

Leela Phadke, Dawn H. W. Lau, Nozie D. Aghaizu…·Sarah Jolly

This paper develops a triculture model of neurons, astrocytes, and microglia to study glia-neuron interactions and their impact on neuronal activity and synapse function.

8 citations

ratexperimental assay

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NeurosciencebioRxivPreprintMay 5, 2022

Microglial expression of the Wnt signalling modulator DKK2 differs between human Alzheimer's disease brains and mouse neurodegeneration models

Nozie D. Aghaizu, Sarah Jolly, Satinder K. Samra…·Paul John Whiting

This study compares microglial DKK2 expression in mouse AD models and human AD brains, finding upregulation in mice but not in humans.

1 citation

mousehuman

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NeuroscienceMolecular PsychiatryPeer-reviewedMar 16, 2022

Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters

Ernest Palomer, Núria Martín‐Flores, Sarah Jolly…·Patricia C. Salinas

The paper identifies Sirt2-induced H4K16ac deacetylation of Fzd1 and Fzd7 promoters as a mechanism repressing Wnt signaling in Alzheimer's disease.

42 citationstop 2%

humanmouse

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