PI3K regulates TAZ/YAP and mTORC1 axes that can be synergistically targeted
Keith C. Garcia, Ali Khan, Krishnendu Ghosh, Sumit Sinha, Nicholas Scalora, Gillian DeWane, Colleen A. Fullenkamp, Nicole M. Merritt, Yuliia Drebot, Samuel Yu, Mariah Leidinger, Michael D. Henry, Patrick John Breheny, Michael S. Chimenti, Munir R. Tanas
This study identifies PI3K-regulated TAZ/YAP and mTORC1 pathways in sarcomas and shows that targeting both synergistically reduces tumor growth.
JCI Insight · Feb 10, 2026Peer-reviewedCancer Biology