The Single-Stranded DNA-Binding Factor SUB1/PC4 Alleviates Replication Stress at Telomeres and is a Vulnerability of ALT Cancer Cells
Jean-Christophe Dubois, Erin Bonnell, A. Jordan Filion, Julie Frion, Samuel Zimmer, Muhammad Riaz Khan, Gabriela Maia Teplitz, Lisa Casimir, Élie Méthot, Isabelle Marois, Mouhamed Idrissou, Pierre‐Étienne Jacques, Raymund J. Wellinger, Alexandre Maréchal
This paper identifies SUB1 as a vulnerability in ALT cancer cells by showing it mitigates telomeric replication stress and that its depletion synergizes with replication stress-inducing therapies.
Proceedings of the National Academy of Sciences · Jan 7, 2025Peer-reviewedCancer Biology