Author

Shalakha Hegde

Johns Hopkins UniversityORCID 0009-0000-7962-4622Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Jingxin WangiD· 2 shared Alexander Y. PantelyatiD· 1 shared Anna LewickaiD· 1 shared Anne CooperiD· 1 shared Chang Qi· 1 shared Chenguang YuiD· 1 shared Erik D. HolmstromiD· 1 shared Gang Ling FengiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBiochemistry

Jingxin WangORCID

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2 papers

Recent·Most cited

BiochemistryProceedings of the National Academy of SciencesPeer-reviewedJul 14, 2026

Targeted α-Synuclein mRNA Degradation by PMO-Based RNA-Degrading Chimeras

Ning Wang, Shalakha Hegde, Zhichao Tang…·Jingxin Wang

This paper develops PMO-based RNA-degrading chimeras that target SNCA mRNA to reduce α-synuclein levels and prevent pathological aggregation in vitro and in vivo.

DOI 10.1073/pnas.2526461123

mousehuman

𝕏 PostBluesky

BiochemistryNucleic Acids ResearchPeer-reviewedJun 5, 2025

Mechanistic Studies of Small Molecule Ligands Selective to RNA Single G Bulges

Shalakha Hegde, Sana Akhter, Zhichao Tang…·Jingxin Wang

This study identifies coumarin derivatives that selectively bind RNA single G bulges, revealing key structural features and using computational and experimental methods to guide rational ligand design.

6 citations

proteomicsdeep learning

𝕏 PostBluesky