YY1 Binding Motif Upstream of Rep/Cap Increases AAV Yield and Full Capsids
Yuri Ofusa, Sanae Nishio, Tatsuji Enoki, Junichi Mineno, Keiya Ozawa, Hiroaki Mizukami, Kenji Ohba
This study shows that inserting the YY1 binding motif upstream of the Rep/Cap gene increases AAV vector yield and improves the empty/full capsid ratio without affecting infectivity.
bioRxiv · Jun 1, 2026 · PreprintMicrobiology