MuSK antibodies differently affect the MuSK signaling cascade depending on valency and epitope specificity
Dana L.E. Vergoossen, Robyn Verpalen, Stine Marie Jensen, Sandra Fonhof, Yvonne E. Fillié‐Grijpma, Christoph Gstöttner, Elena Domínguez‐Vega, Silvère M. van der Maarel, Jan J.G.M. Verschuuren, Maartje G. M. Huijbers
This study investigates how valency and epitope specificity of MuSK antibodies affect MuSK signaling, revealing distinct impacts on binding kinetics, Dok7 binding, and gene expression.
Journal of Autoimmunity · Jul 2, 2026Peer-reviewedImmunology