The epigenetic reader MORC3 is required for T cell development in the thymus
Veronica Della Chiara, Maja Vukić, Jihed Chouaref, Laura García-Pérez, Gita Naber, Kelly K. D. Vonk, Christ Leemans, Artemiy Kovynev, Zhenhui Zhong, Cor Breukel, Sandra G. Vloemans, Kirsten Canté-Barrett, Karin Pike‐Overzet, Steven E. Jacobsen, Frank J. T. Staal, Lucia Daxinger
This study shows that MORC3 is essential for T cell development in the thymus, as its loss causes developmental arrest and altered chromatin accessibility in DN1 cells.
bioRxiv · Mar 5, 2025 · PreprintGenetics