Author

Frank J. T. Staal

Leiden University Medical CenterORCID 0000-0003-1588-8519Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 2 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Assay:ATAC-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

Karin Pike‐OverzetiD· 2 shared Kirsten Canté-BarrettiD· 2 shared Ahmet F. CoskuniD· 1 shared Aline ZbindeniD· 1 shared Artemiy KovyneviD· 1 shared Brandon F. KeeleiD· 1 shared Christ LeemansiD· 1 shared Christian Michel BeuschiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersImmunology

Karin Pike‐OverzetORCID

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3 papers

Recent·Most cited

ImmunologybioRxivPreprintMay 26, 2026

Multi-omic profiling of human thymic B cells reveals intrathymic Ig-class switching and differentiation into multiple memory B cell subsets

Martijn Cordes, Erik B. van den Akker, Janine E. Melsen…·Kirsten Canté-Barrett

The paper identifies and characterizes distinct B cell subsets in the human thymus, revealing their development, differentiation, and class switching capabilities.

DOI 10.64898/2026.05.21.725517

humanscRNA-seq

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ImmunologybioRxivPreprintFeb 2, 2026

Interleukin-6 restricts pre-thymic T cell lineage commitment of progenitors driving loss of SIV control

Saleem Anwar, Naseem Sadek, Christian Michel Beusch…·Sheikh Abdul Rahman

This study shows that IL-6 restricts pre-thymic T cell lineage commitment in SIV-infected rhesus macaques, contributing to loss of viral control.

DOI 10.64898/2026.01.29.702123

ratbulk RNA-seq

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GeneticsbioRxivPreprintMar 5, 2025

The epigenetic reader MORC3 is required for T cell development in the thymus

Veronica Della Chiara, Maja Vukić, Jihed Chouaref…·Lucia Daxinger

This study shows that MORC3 is essential for T cell development in the thymus, as its loss causes developmental arrest and altered chromatin accessibility in DN1 cells.

DOI 10.1101/2025.03.05.641591

mouseATAC-seq

𝕏 PostBluesky