Overactive PDGFRα and PDGFRβ promote distinct yet overlapping phenotypes of skeletal muscle fibrosis and stiffness, with PDGFRβ also driving drastic muscle growth
Mariola Gimła, Szczepan S. Olszewski, Jacob L. Brown, Christiana J. Raymond‐Pope, Sandra Rigsby, Frederick F. Peelor, Hae Ryong Kwon, Longbiao Yao, Lorin E. Olson, Jordan D. Fuqua, Benjamin F. Miller
This study shows that overactive PDGFRα and PDGFRβ signaling in mice leads to distinct but overlapping fibrotic and growth-related muscle changes, with sex-specific effects.
bioRxiv · Jan 2, 2026 · PreprintPhysiology